Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial.
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial.
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
Magnesium reduces postoperative knee pain
Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial.
We evaluated the impact of magnesium sulphate on pain levels for 44 patients undergoing staged bilateral total knee arthroplasty.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
Read More
Most Useful Reviews
9
Knee improvement noted
16 people found this helpful
Great value for money! This magnesium chelate, with glycine and lysine, promotes relaxation, especially when taken before bed. My knee arthrosis has improved significantly, and I wholeheartedly recommend it. If you find this helpful, please give it a like!
Read More
9
Knee pain improvement
6 people found this helpful
I noticed a distinction in my bones and muscles after I started the supplement. Combined with a proper sleep routine, it has helped ease my insomnia. I feel revitalised every morning, and my knees and legs feel much better. The absorption seems to have improved as well. I'll definitely reorder soon!
Read More
7.5
Knee recovery
28 people found this helpful
I had to switch to a pricier liposomal magnesium after experiencing stomach upset with this one. Despite that, magnesium has notably reduced my fatigue and remarkably aided my recovery from a knee ligament strain. I suggest finding a tolerable version if this one doesn’t suit you. Please thumbs up if you find this helpful!
Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial.
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial.
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
Magnesium and bupivacaine effective
Intra-Articular Magnesium Plus Bupivacaine Is the Most Effective and Safe Postoperative Analgesic Option Following Knee Arthroscopy: A Network Meta-analysis.
We evaluated how effective magnesium, especially when combined with bupivacaine, is for managing knee pain after arthroscopy. Our study looked at data from 78 randomized trials involving 4,425 participants.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
Read More
9
Magnesium reduces postoperative knee pain
Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial.
We evaluated the impact of magnesium sulphate on pain levels for 44 patients undergoing staged bilateral total knee arthroplasty.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
Read More
9
Magnesium reduces post-surgery pain
Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty.
We looked into how magnesium can help ease knee pain after total knee arthroplasty. In a study of 80 patients, those who received an injection of magnesium sulfate and ropivacaine experienced significantly less pain and needed less morphine compared to those who got a saline injection. This approach not only reduced morphine use in the first 48 hours but also allowed patients to regain movement quicker. Overall, our findings suggest that magnesium may be a beneficial part of pain management in knee surgery.
Great value for money! This magnesium chelate, with glycine and lysine, promotes relaxation, especially when taken before bed. My knee arthrosis has improved significantly, and I wholeheartedly recommend it. If you find this helpful, please give it a like!
Read More
9
Knee pain improvement
6 people found this helpful
I noticed a distinction in my bones and muscles after I started the supplement. Combined with a proper sleep routine, it has helped ease my insomnia. I feel revitalised every morning, and my knees and legs feel much better. The absorption seems to have improved as well. I'll definitely reorder soon!
Read More
7.5
Knee recovery
28 people found this helpful
I had to switch to a pricier liposomal magnesium after experiencing stomach upset with this one. Despite that, magnesium has notably reduced my fatigue and remarkably aided my recovery from a knee ligament strain. I suggest finding a tolerable version if this one doesn’t suit you. Please thumbs up if you find this helpful!
Read More
7.5
Knee relief attained
2 people found this helpful
I initially bought this magnesium for myself but realised it could help my husband. He takes two tablets each morning and night. Surprisingly, he only needs one in the morning. He and his knees have benefited greatly, resulting in improved sleep for both of us. I recommend it for peace of mind.
Read More
6
Knee noise stopped
2 people found this helpful
Great vitamins! After three weeks, I've noticed much less fatigue. I have difficulty getting up in the mornings and have noticed my knee no longer creaks. My energy levels during training have increased, and my cravings for sweets have diminished. I highly recommend it!
Knee pain is a common condition that can result from various causes, including injuries, overuse, and underlying medical conditions such as arthritis. The knee joint is a complex structure composed of bones, ligaments, tendons, and cartilage, all of which work together to enable movement and support body weight. When any of these components are damaged or inflamed, it can lead to discomfort, stiffness, swelling, and reduced mobility in the affected area.
In many cases, knee pain can manifest as acute pain following an injury, such as a tear in a ligament or cartilage damage. Alternatively, it may develop gradually due to factors like repetitive strain, age-related degeneration, or conditions like osteoarthritis and rheumatoid arthritis. Treatment options vary widely and may include rest, physical therapy, medication, or, in severe cases, surgical interventions. If you're experiencing persistent knee pain, it's advisable to consult with a healthcare professional for an accurate diagnosis and tailored treatment plan.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is an essential mineral that plays a critical role in numerous bodily functions, including muscle and nerve function, which can be beneficial in managing pain. While it is not a direct treatment for knee pain, some studies suggest that magnesium can help reduce inflammation and improve muscle function, which might alleviate discomfort associated with conditions such as arthritis or strains in the knee area. Magnesium deficiency has also been linked to increased inflammation, so ensuring adequate magnesium levels could potentially support overall joint health.
However, it's important to note that magnesium should not be considered a standalone solution for knee pain. It's best to adopt a comprehensive approach that includes other treatments such as physical therapy, proper exercise, and possibly anti-inflammatory medications recommended by healthcare providers. Always consult with a medical professional before starting any new supplementation, especially if you have existing health concerns or are taking other medications.
Based on user reviews, individuals typically start noticing improvements in knee pain within a few weeks of taking magnesium supplements. For instance, one user reported significant improvement in their knee arthrosis after a few weeks of use, highlighting its effectiveness for alleviating knee pain (Read Review). Another reviewer noted that after three weeks, their knee no longer creaked, indicating a notable reduction in discomfort and a positive change in their overall energy levels and fatigue (Read Review).
While some users experienced relief sooner, others suggested a gradual improvement, emphasizing the importance of consistent use along with a healthy lifestyle. For example, one user described how magnesium helped ease their knee pain while also enhancing their overall well-being, demonstrating that results can vary based on individual circumstances and your body's response to the supplement (Read Review). Overall, most users seem to agree that with regular intake, noticeable results can be observed within a few weeks.
The scientific research supports the use of magnesium in managing knee pain, particularly in the context of postoperative recovery. Several studies have demonstrated that magnesium sulfate can significantly reduce pain levels and improve recovery outcomes for patients after knee surgeries such as total knee arthroplasty. For example, research found that patients who received magnesium sulfate experienced lower pain scores and reduced opioid usage compared to those who did not receive it ([1]; [2]; [3]). These findings suggest that magnesium can enhance analgesic protocols and contribute to a smoother recovery process.
Additionally, magnesium appears to perform well when combined with other analgesics. Studies have indicated that integrating magnesium with bupivacaine and other pain relief methods results in superior pain control without increasing side effects ([6]; [15]). Thus, the weight of the evidence points to magnesium as a promising adjunct in the management of knee pain, particularly in the postoperative setting, making it a worthwhile consideration for those seeking effective pain relief strategies.
Based on user reviews, many individuals have reported various improvements in their symptoms after taking magnesium supplements. Notably, users have highlighted enhanced comfort in their knees and joints, with one individual noting significant improvement in knee arthrosis and another marking the absence of creaking in their knees after three weeks (Read ReviewRead Review). Some users also mentioned a general feeling of revitalization, with reports of better sleep and reduced fatigue contributing to an overall boost in daily energy levels (Read ReviewRead Review).
Additionally, magnesium's capacity to relieve muscle tension and stress has been referenced, with long-term users claiming substantial positive changes in their mood and energy levels, suggesting that consistent use, in combination with a healthy lifestyle, could lead to improvements over time (Read ReviewRead Review). While individual experiences vary—and some users have had to switch to different formulations due to side effects—many testimonials depict magnesium as a beneficial addition to their wellness routines.
Based on user reviews, many individuals have reported positive effects when combining this magnesium supplement with other supplements or lifestyle adjustments for managing knee pain. One user noted that alongside a proper sleep routine, taking magnesium has resulted in significant improvements in their knees and legs, indicating that a holistic approach can enhance the supplement's efficacy (Read Review). Another reviewer specifically mentioned that the combination of magnesium with other vitamins contributed to their enhanced energy and reduced fatigue, further supporting their recovery from knee issues (Read Review).
However, users have also reported challenges when integrating magnesium into their routines. One individual had to switch to a different formulation due to stomach upset but still found benefits from magnesium in reducing fatigue and helping with recovery from a knee ligament strain (Read Review). This suggests that while magnesium can be beneficial for knee pain management, paying attention to personal tolerance and possibly combining it with other supplements may be necessary to achieve optimal results.
Users report varying dosages of magnesium are effective for treating knee pain, with many emphasizing the importance of finding the right amount for personal tolerance. For instance, one user noted they took 100 mg three to four times a day to enhance absorption, which helped alleviate their knee discomfort significantly (Read Review). Another user mentioned their husband benefited from just one tablet in the morning, indicating that individual responses to dosage can vary widely (Read Review).
Additionally, some users experienced relief from knee pain after a short period of consistent use, suggesting that maintaining a routine could play a role in effectiveness. For example, one reviewer shared that after three weeks of use, their knee no longer creaked and their energy levels improved during physical training (Read Review). Overall, users advocate for experimenting with different dosages to determine what works best for individual needs while keeping an eye on how their knee pain responds.
9
Knee improvement noted
16 people found this helpful
Great value for money! This magnesium chelate, with glycine and lysine, promotes relaxation, especially when taken before bed. My knee arthrosis has improved significantly, and I wholeheartedly recommend it. If you find this helpful, please give it a like!
6
Knee noise stopped
2 people found this helpful
Great vitamins! After three weeks, I've noticed much less fatigue. I have difficulty getting up in the mornings and have noticed my knee no longer creaks. My energy levels during training have increased, and my cravings for sweets have diminished. I highly recommend it!
7
Knee pain support
15 people found this helpful
I purchased this magnesium for its dosage and quality. I take 100 mg three to four times a day for better absorption. It helps me sleep better, and while my knee still hurts, magnesium significantly aids this. The capsules are easy to swallow, making it a convenient choice.
9
Knee pain improvement
6 people found this helpful
I noticed a distinction in my bones and muscles after I started the supplement. Combined with a proper sleep routine, it has helped ease my insomnia. I feel revitalised every morning, and my knees and legs feel much better. The absorption seems to have improved as well. I'll definitely reorder soon!
7.5
Knee relief attained
2 people found this helpful
I initially bought this magnesium for myself but realised it could help my husband. He takes two tablets each morning and night. Surprisingly, he only needs one in the morning. He and his knees have benefited greatly, resulting in improved sleep for both of us. I recommend it for peace of mind.
8
Stress and anxiety relief
This supplement is fantastic! It effectively helps relieve muscle tension and tension. Magnesium deficiency manifests in various ways, and I realised its importance over time. My experience has greatly improved; I feel balanced and my weather-related mood swings are gone.
8
Balanced mood achievement
An excellent magnesium supplement that enhances muscle tension relief! Magnesium deficiency presents itself in various symptoms, which I successfully addressed by supplementing magnesium. Two years on, I’ve transformed from a chronically tense individual to a more peaceful person.
7.5
Knee recovery
28 people found this helpful
I had to switch to a pricier liposomal magnesium after experiencing stomach upset with this one. Despite that, magnesium has notably reduced my fatigue and remarkably aided my recovery from a knee ligament strain. I suggest finding a tolerable version if this one doesn’t suit you. Please thumbs up if you find this helpful!
8
Magnesium aids post-surgery pain relief
Magnesium sulphate and sodium bicarbonate as additives for periarticular local infiltration analgesia improve pain management after unicompartmental knee arthroplasty: a prospective, double-blind, randomized controlled trial.
We investigated the impact of magnesium sulphate in pain management for patients after unicompartmental knee arthroplasty (UKA). In a controlled trial, 61 patients received either a modified pain relief cocktail with magnesium or a traditional one.
Results showed that the modified cocktail led to less pain medication use and improved early joint recovery. In other words, magnesium seemed to enhance pain control and recovery without the use of additional drugs.
7
Magnesium aids knee surgery recovery
Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial.
We investigated how magnesium sulfate influences recovery after knee surgery. In our study, 148 elderly patients undergoing total knee arthroplasty were divided into two groups: one received magnesium sulfate, while the other received a saline solution.
This double-blind setup allowed us to see if magnesium sulfate could enhance recovery quality after surgery. Our findings indicate that magnesium sulfate does help reduce early postoperative pain and improves overall recovery in these patients.
Overall, magnesium sulfate appears beneficial in managing pain during the recovery process.
9
Magnesium sulfate alleviates postoperative pain
Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial.
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Intra-Articular Magnesium Plus Bupivacaine Is the Most Effective and Safe Postoperative Analgesic Option Following Knee Arthroscopy: A Network Meta-analysis.
We evaluated how effective magnesium, especially when combined with bupivacaine, is for managing knee pain after arthroscopy. Our study looked at data from 78 randomized trials involving 4,425 participants.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
9
Magnesium reduces post-surgery pain
Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty.
We looked into how magnesium can help ease knee pain after total knee arthroplasty. In a study of 80 patients, those who received an injection of magnesium sulfate and ropivacaine experienced significantly less pain and needed less morphine compared to those who got a saline injection. This approach not only reduced morphine use in the first 48 hours but also allowed patients to regain movement quicker. Overall, our findings suggest that magnesium may be a beneficial part of pain management in knee surgery.
References
Zhu Y, Shen S, Cui L, Wu L, Zhang B. Magnesium sulphate and sodium bicarbonate as additives for periarticular local infiltration analgesia improve pain management after unicompartmental knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2024;19:764. doi:10.1186/s13018-024-05233-6
Xu H, Hao C, Wang X, Du J, Zhang T, et al. Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial. Drug Des Devel Ther. 2024;18:919. doi:10.2147/DDDT.S444896
Zhao C, Wang L, Chen L, Wang Q, Kang P. Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2023;18:301. doi:10.1186/s13018-023-03790-w
Wang Q, Zhao C, Hu J, Ma T, Yang J, et al. Efficacy of a Modified Cocktail for Periarticular Local Infiltration Analgesia in Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized Controlled Trial. J Bone Joint Surg Am. 2023;105:354. doi:10.2106/JBJS.22.00614
Choi JW, Lahori A, Merlo JA, Gill O, Ghoddoussi F, et al. Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial. Clin J Pain. 2022;38:388. doi:10.1097/AJP.0000000000001036
He Y, He H, Li X, Lei G, Xie D, et al. Intra-Articular Magnesium Plus Bupivacaine Is the Most Effective and Safe Postoperative Analgesic Option Following Knee Arthroscopy: A Network Meta-analysis. Arthroscopy. 2022;38:2897. doi:10.1016/j.arthro.2022.03.013
Shi L, Zhu H, Ma J, Shi LL, Gao F, et al. Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:111. doi:10.1186/s13018-021-02264-1
Zhao Z, Zhang X, Peng H, Li W, Liu H, et al. Magnesium Sulfate Combined with a Levobupivacaine Periarticular Cocktail for Analgesia in the Early Postoperative Period after Total Knee Arthroplasty. J Knee Surg. 2021;34:1463. doi:10.1055/s-0040-1710364
Condello V, Filardo G, Madonna V, Andriolo L, Screpis D, et al. Use of a Biomimetic Scaffold for the Treatment of Osteochondral Lesions in Early Osteoarthritis. Biomed Res Int. 2018;2018:7937089. doi:10.1155/2018/7937089
Shmagel A, Onizuka N, Langsetmo L, Vo T, Foley R, et al. Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2018;26:651. doi:10.1016/j.joca.2018.02.002
Shin HJ, Kim EY, Na HS, Kim TK, Kim MH, et al. Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial. Br J Anaesth. 2016;117:497. doi:10.1093/bja/aew227
Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2012;40:2032.
Ekmekci P, Bengisun ZK, Akan B, Kazbek BK, Ozkan KS, et al. The effect of magnesium added to levobupivacaine for femoral nerve block on postoperative analgesia in patients undergoing ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2013;21:1119. doi:10.1007/s00167-012-2093-4
Koltka K, Koknel-Talu G, Asik M, Ozyalcin S. Comparison of efficacy of intraarticular application of magnesium, levobupivacaine and lornoxicam with placebo in arthroscopic surgery. Knee Surg Sports Traumatol Arthrosc. 2011;19:1884. doi:10.1007/s00167-011-1497-x
Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2009;37:1733.
Farouk S, Aly A. A comparison of intra-articular magnesium and/or morphine with bupivacaine for postoperative analgesia after arthroscopic knee surgery. J Anesth. 2009;23:508. doi:10.1007/s00540-009-0822-8